Boston's Daisuke Matsuzaka was strong against the Blue Jays, striking out ten and only giving up three hits, but it wasn't enough as Toronto defeated the Red Sox, 2-1.
The Japanese star had a tough 4th inning when he walked Greg Zaun with the bases loaded, giving Toronto the lead.
Gustavo Chacin picked up his second win of the season, while Jason Frasor recorded the save.
Game two is tonight at the Rogers Centre; Tomo Okha (0-1) will face Boston's Tim Wakefield (1-1).
First pitch is at 7:07pm.
With Chris Bosh and Anthony Parker getting the night off, the Raptors lost to the Detroit Pistons, 100-84.
The Raps had an injury scare, when Morris Peterson hyperexteded his right knee.
However, the veteran forward doesn't expect to miss any action.
Peterson will be evaluated later today.
The Raptors will host the Philadelphia 76ers in their final regular season match.
Tip off is at 7pm at the Air Canada Centre.
Two more players have joined the Toronto FC.
English striker Danny Dichio has been added to the roster as well as defender Marvel Wynne, who was picked up in a trade with the New York Red Bulls.
Scoreboard
NHL Playoffs
Ottawa 2 Pittsburgh 1 (Ott. leads 3-1)
Calgary 3 Detroit 2 (Det. leads 2-1)
Vancouver 2 Dallas 1 (Van. leads 3-1)
N.Y. Rangers 7 Atlanta 0 (NYR leads 3-0)
Minnesota 4 Anaheim 1 (Ana leads 3-1)
- ER